Anticancer Download Ebook PDF Epub Online

Author : David Servan-Schreiber
Publisher : Penguin Books
Release : 2017-10-03
Page : 288
Category : Health & Fitness
ISBN 13 : 9780452295728
Description :


The revolutionary, New York Times bestselling guide to the powerful lifestyle changes that fight and prevent cancer--an integrative approach based on the latest scientific research "A common-sense blueprint for healthy living." --Chicago Tribune "Resonating with cancer support communities and recommended nationwide." --Los Angeles Times "Life affirming . . . filled with practical advice." --The Seattle Times David Servan-Schreiber was a rising neuroscientist with his own brain imaging laboratory when, in the middle of an equipment test, he discovered a tumor the size of a walnut in his own brain. Forced to confront what medicine knows about cancer, and all that we still do not know, Servan-Schreiber marshaled his will to live and set out to understand the complex inner workings of the body's natural cancer-fighting capabilities. He soon found himself on a decades-long journey from disease and relapse into scientific exploration and, finally, a new view of health. Anticancer is at once the moving story of one doctor's inner and outer search for wellness and a radical exposition of the roles that lifestyle, environment, and trauma play in our health. Drawing on the latest research in integrative medicine that blends conventional and alternative approaches, Servan-Schreiber concisely explains what makes cancer cells thrive, what inhibits them, and how we can empower ourselves to prevent their growth. His advice details how to develop a science-based anticancer diet (and the small changes that can make a big difference); how to reap the benefits of exercise, yoga, and meditation; which toxic, unsafe products to replace in your home; and how to stave off the effects of helplessness and unhealed wounds to regain balance. Anticancer's synthesis of science and personal experience marks a transformation in the way we understand and confront cancer. A long-running bestseller that has changed the lives of millions around the world, Anticancer remains a pioneering and peerless resource, an inspirational and revolutionary guide to "a new way of life."


Author : Lorenzo Cohen PhD
Alison Jefferies, MEd
Publisher : Penguin
Release : 2018-05-01
Page : 432
Category : Health & Fitness
ISBN 13 : 0735220425
Description :


“An invaluable guide for both professionals in the health field and the general public.” —Deepak Chopra, MD The evidence is in: you can reduce cancer risk and support treatment by focusing on six key areas of health and wellness. The scientific data on the link between lifestyle, environmental factors, and cancer risk has been accumulating at an accelerated rate over the past decade: Every week we learn something more that we can do as individuals to decrease the risk of can­cer and improve the likelihood of long-term survival. Many of us—patients and doctors included—do not realize that changes in our daily choices and habits can improve quality of life, increase the chances of survival, and aid in the healing process for those with a diagnosis. These ideas were pioneered in David Servan-Schreiber’s Anticancer: A New Way of Life, and became the basis for a research study developed by Lorenzo Cohen and Servan-Schreiber at The University of Texas MD Anderson Cancer Center. Introducing the concept of the “Mix of Six,” Cohen and Alison Jefferies make an informed case that building social and emotional support; manag­ing stress; improving sleep, exercise, and diet; and minimizing exposure to environmental toxins work together to promote an optimal environment for health and well-being. While each plays an inde­pendent role, the synergy created by all six factors can radically transform health; delay or prevent many cancers; support conventional treatments; and significantly improve quality of life—as many testi­monies and stories of those in the anticancer com­munity eloquently show. Anticancer Living provides an accessible, pre­scriptive guide to wellness based on the latest scien­tific findings and clinical trials, and it showcases the community of doctors, researchers, caregivers, and patients who have been inspired to create change.


Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Release : 2013-11-11
Page : 311
Category : Medical
ISBN 13 : 1461581524
Description :


Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe the arduous process of cancer drug discovery and approval. They focus on using preclinical in vivo and in vitro methods to identify molecules of interest, detailing the targets and criteria for success in each type of testing and defining the value of the information obtained from the various tests. They also define each stage of clinical testing, explain the criteria for success, and outline the requirements for FDA approval. A companion volume by the same editor (Cancer Therapeutics: Experimental and Clinical Agents) reviews existing anticancer drugs and potential anticancer therapies. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.


Author : Bruce C. Baguley
David J. Kerr
Publisher : Elsevier
Release : 2001-11-17
Page : 397
Category : Medical
ISBN 13 : 9780080490441
Description :


Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching


Author : Soodabeh Saeidnia
Publisher : Springer
Release : 2015-02-05
Page : 106
Category : Medical
ISBN 13 : 3319140272
Description :


This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.


Author : Gordon M. Cragg
David G. I. Kingston
Publisher : CRC Press
Release : 2011-10-10
Page : 767
Category : Science
ISBN 13 : 1439813825
Description :


The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.


Author : Adam Todd
Paul W. Groundwater
Publisher : John Wiley & Sons
Release : 2018-02-20
Page : 448
Category : Medical
ISBN 13 : 111862212X
Description :


An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.


Author : Lorenzo Cohen
Alison Jefferies
Publisher : Vermilion
Release : 2018-05
Page : 288
Category : Cancer
ISBN 13 : 9781785040757
Description :


The revolutionary, science-based plan to reclaim your health"You have cancer." These are perhaps the most feared three words that will ever come out of a doctor?s mouth, and more and more people are hearing them. Yet most patients (and some doctors) do not realize that lifestyle changes can dramatically reduce risk, assist treatment and improve chances of surviving and even thriving after a diagnosis. Over the course of a major study Servan-Schreiber designed with Dr Lorenzo Cohen at the MD Anderson Cancer Center, six key areas have emerged- love and social support, stress management, rest, movement, nutrition and avoiding environmental toxins. Each plays a role--but it's the synergies created by this potent "Mix of Six" that can bring about real shifts in health and well-being, significantly improving quality of life and positively supporting conventional cancer treatments.Dr. David Servan-Schreiber's Anticancer introduced a revolutionary way to understand and confront cancer, changing the lives of millions around the world. He laid out the principles of integrative care that had allowed him to live many years beyond expectations for his own cancer, but readers have long requested a specific plan to implement his approach. Anticancer Living is that book.


Author : Loutfy H. Madkour
Publisher : Academic Press
Release : 2019-08-27
Page : 650
Category : Business & Economics
ISBN 13 : 0128197781
Description :


Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy


Author : Alex A. Adjei
John K. Buolamwini
Publisher : Academic Press
Release : 2011-04-28
Page : 464
Category : Medical
ISBN 13 : 0080537758
Description :


This book offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. * Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field * Presents drug discovery strategies * Discusses regulatory issues surrounding drug development *


Author : Niamh M O’Boyle
Mary J Meegan
Publisher : MDPI
Release : 2019-10-11
Page : 214
Category : Medical
ISBN 13 : 3039215868
Description :


The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody–drug conjugates, with articles covering a variety of anticancer therapies and potential relevant disease states and applications. Significant efforts are being made to develop and improve cancer treatments and to translate basic research findings into clinical use, resulting in improvements in survival rates and quality of life for cancer patients. We demonstrate the possibilities and scope for future research in these areas and also highlight the challenges faced by scientists in the area of anticancer drug development leading to improved targeted treatments and better survival rates for cancer patients.


Author : Sotiris Missailidis
Publisher : John Wiley & Sons
Release : 2008-10-13
Page : 424
Category : Science
ISBN 13 : 0470697032
Description :


Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.


Author : Michael Waring
B.A. Ponder
Publisher : Springer
Release : 2011-09-28
Page : 296
Category : Medical
ISBN 13 : 9789401066594
Description :


Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science. This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome, then (DNA in biochemical terms), surely represents a critical target for specific chemotherapy of cancer, and several chapters address the issue of attacking DNA, gene targetting, and the like. Others deal with principles of rational design, exploitation of novel modalities and targets, or the nuts and bolts of antitumour drug testing. While no attempt has been made to provide a comprehensive coverage of this wide-ranging and vitally important subject, the present volume in the series will provide much food for thought.


Author : William C.S. Cho
Publisher : Springer Science & Business Media
Release : 2011-03-29
Page : 442
Category : Medical
ISBN 13 : 9789400705265
Description :


Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments’ side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Recently there have been encouraging results from both laboratory experiments and clinical trials demonstrating the anticancer effects of herbal medicine. There is considerable interest among oncologists and cancer researchers to find anticancer agents in herbal medicine. This volume is a specialised book presenting the up-to-date scientific evidence for anticancer herbal medicine. This unique book provides an overview of the anticancer herbal medicines and remedies, as well as a detailed evidence-based evaluation of 18 common anticancer herbal medicines covering their biological and pharmacological properties, efficacies, herb-drug interactions, adverse effects, pre-clinical studies, and clinical applications. Gathering international opinion leaders’ views, this volume will contribute great to the cancer, academic, and clinical community by providing evidence-based information on the anticancer efficacy of herbal medicine. Readership Oncologists, cancer researchers, pharmacologists, pharmaceutical specialists, Chinese medicine practitioners, medical educators, postgraduates and advanced undergraduates in biomedical disciplines, cancer caregivers, cancer patients.


Author : David E. Thurston
Ilona Pysz
Publisher : CRC Press
Release : 2021-03-18
Page : 594
Category : Medical
ISBN 13 : 1315357089
Description :


While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines. Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"


Author : Stefan Grimm
Publisher : Springer
Release : 2014-07-08
Page : 283
Category : Science
ISBN 13 : 144716458X
Description :


This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide, Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research, molecular medicine, pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.


Author : Michelle A. Rudek
Cindy H. Chau
Publisher : Springer Science & Business Media
Release : 2014-01-10
Page : 836
Category : Medical
ISBN 13 : 1461491355
Description :


There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development


Author : Mohd Sayeed Akhtar
Mallappa Kumara Swamy
Publisher : Springer
Release : 2018-06-29
Page : 582
Category : Science
ISBN 13 : 981108548X
Description :


Cancer is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though, several synthetic medicines are useful in treating cancer, they are inefficient and unsafe. However, plants have proved to be useful in cancer cure. Moreover, natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types. The anticancer plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays, several well-known anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences, the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence, there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities. Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis. We acknowledge the publisher, Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support, and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics, pharmaceuticals, nutraceuticals and medical practitioners.


Author : Wolfgang Link
Publisher : Springer Nature
Release : 2019-09-10
Page : 145
Category : Medical
ISBN 13 : 3030187225
Description :


This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.


Author : David E. Thurston
Publisher : CRC Press
Release : 2006-11-22
Page : 312
Category : Medical
ISBN 13 : 1420008900
Description :


While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents currently in use or in advanced stages of clinical trials, including biologicals. The book is unique in providing molecular structures for all anticancer drugs, discussing them in terms of history, chemistry, mechanism of action, structure-function relationships, and pharmacology. It also provides some relevant information on side effects, dosing, and formulation. The author, a renowned scientist in cancer research and drug development, also provides up-to-date information on the drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in the emerging areas of personalized medicine (e.g., oncogenomics) and chemoprevention. Chemistry and Pharmacology of Anticancer Drugsis an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new anticancer treatments. Its breadth of coverage also makes it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, and related disciplines.