Contemporary Management Of Intracranial Metastatic Disease Download Ebook PDF Epub Online

Author : Sunit Das
Arjun Sahgal
Publisher : Frontiers Media SA
Release : 2019-10-17
Page :
Category :
ISBN 13 : 288963129X
Description :


The development of intracranial metastatic disease (IMD) complicates the course of 20% of patients with cancer. Despite improvements in patient survival with more aggressive treatment options as compared to the prior standard of palliative whole brain radiation, outcomes for patients who develop IMD remain dispiriting. There is need to celebrate our advances; but a major collaborative multidisciplinary effort is needed to push the field to achieve more meaningful survival benefits for our patients with IMD. In this Research Topic collection, we have assembled work detailing the latest innovations in brain metastases imaging and management, spanning from minimally invasive surgery to immunotherapy. We hope that you find it a valuable resource.


Author : Ganesh Rao
Anthony D'Ambrosio
Publisher : Saunders
Release : 2010-12
Page : 109
Category : Medical
ISBN 13 : 9781455704712
Description :


Drs. Rao and D'Ambrosio will devote twelve chapters to brain metastases, covering all areas including the epidemiology, neuroimaging, and molecular biology of brain metastases, as well as surgical, medical, and radiosurgical management. The issue will also include chapters on evidence-based guidelines, investigational therapies, neurocognitive and quality of life measures, and more.


Author : M. A. Hayat
Publisher : Academic Press
Release : 2016-04-07
Page : 384
Category : Science
ISBN 13 : 0128035595
Description :


Brain Metastases from Primary Tumors Volume Three: Epidemiology, Biology, and Therapy of Melanoma and Other Cancers provides a comprehensive overview of the metastasis of cancer, the main cause of approximately 90% of cancer associated deaths, yet the mechanisms governing this clinically important process remain poorly understood. Melanoma is the third most common diagnosis among patients with brain metastases, after lung and breast cancer. Approximately 75% of patients with metastatic melanoma develop brain metastases during the course of their disease. Although tumorigenesis of melanoma remains poorly understood, recent advances in gene expression profiling have revealed molecular mechanisms of this deadly disease. In addition, high-throughput gene expression has many advantages over techniques in cancer transcriptomic studies and has led to the discovery of numerous diagnostic, prognostic, and therapeutic targets, which are also detailed in this book. The book discusses the link between primary tumors and brain metastasis of melanoma, including molecular mechanisms, treatment options, prognosis, and general applications. Comprehensive chapters discuss systemic therapy, integrin inhibitors, stereotaxic radiosurgery, and more, making this book a great resource for neurooncologists, neurosurgeons, neurologists, and cancer researchers. Presents the only comprehensive reference detailing the link between primary cancers and brain metastases in melanoma Aids the target audience in discussing various treatment options for patients with brain metastases from melanoma Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available


Author : A. Niranjan
L.D. Lunsford
Publisher : Karger Medical and Scientific Publishers
Release : 2019-05-20
Page : 322
Category : Medical
ISBN 13 : 331806422X
Description :


Since its introduction 52 years ago, Leksell radiosurgery has become a widely applied technique for the management of a diverse group of vascular, neoplastic, and functional disorders. This publication presents an update on state-of-the-art radiosurgery technology, including outcomes, by the pioneers in the field. Experts have contributed chapters on various topics. They provide a history of the development of Leksell Gamma Knife and its evolution from frame-based to the inclusion of mask-based radiosurgery in the latest Gamma Knife model. For beginners, there is valuable information related to imaging, quality assurance, patient care, anesthesia, and regulatory requirements. Advance users will appreciate the summary of the long-term outcome of important indications. Additional chapters on cavernous malformation, orbital, uveal, and ocular disorders clarify the role of radiosurgery. This book is a concise overview for physicians interested in radiosurgery. It will be of great value to neurosurgeons, radiation oncologists, and medical physicists concerned with learning about the indications of radiosurgery.


Author : Giuseppe Giaccone
Publisher : Oxford University Press
Release : 2012-05-31
Page : 128
Category : Medical
ISBN 13 : 0199580480
Description :


This pocketbook summarises the latest evidence-based and practical information on the use of systemic therapies in the management of non-small cell lung cancer (NSCLC) for early stage, locally advanced, and metastatic disease.


Author : Rohan Ramakrishna
Rajiv S Magge
Publisher : Springer
Release : 2021-06-11
Page : 734
Category :
ISBN 13 : 9783030429607
Description :


This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy. Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.


Author : Lisa M. DeAngelis
Jerome B. Posner
Publisher : OUP USA
Release : 2009
Page : 634
Category : Language Arts & Disciplines
ISBN 13 : 0195366743
Description :


The final section addresses several nonmetastatic complications of cancer and includes sections on vascular disease, infections, metabolic and nutritional disorders, side effects of chemotherapy and radiation, and other diagnostic and therapeutic procedures and concludes with a discussion on paraneoplastic syndromes."


Author : Simon S. Lo
Bin S. Teh
Publisher : Springer Science & Business Media
Release : 2012-08-28
Page : 421
Category : Medical
ISBN 13 : 364225604X
Description :


Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.


Author : Michael E. Sughrue
Isaac Yang
Publisher : Academic Press
Release : 2019-08-03
Page : 256
Category : Medical
ISBN 13 : 0128136340
Description :


New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients. Provides the first comprehensive book to discuss techniques for removing gliomas that are traditionally deemed ‘inoperable’ Presents a great reference tool that challenges stereotypical thinking by offering techniques by innovative surgeons Includes chapters that are organized by different glioma types and surgery/techniques


Author :
Publisher :
Release : 19??
Page :
Category :
ISBN 13 : 9789535130529
Description :



Author : Russell R. Lonser
J. Bradley Elder
Publisher : Neurosurgery by Example
Release : 2018-11-09
Page : 312
Category : Medical
ISBN 13 : 0190696699
Description :


Part of the Neurosurgery by Example series, this volume on surgical neuro-oncology presents exemplary cases in which renowned authors guide readers through the assessment and planning, decision making, surgical procedure, after care, and complication management of common and uncommon disorders. The cases explore a number of different types of nervous systems tumors, including glioblastoma, medulloblastoma, skull tumors, and more. Each chapter also contains 'pivot points' that illuminate changes required to manage patients in alternate or atypical situations, and pearls for accurate diagnosis, successful treatment, and effective complication management. Containing a focused review of medical evidence and expected outcomes, Surgical Neuro-Oncology is appropriate for neurosurgeons who wish to learn more about this subspecialty, and those preparing for the American Board of Neurological Surgery oral examination.


Author : Manmeet Ahluwalia
Philippe Metellus
Publisher : Springer
Release : 2020-11-29
Page : 421
Category : Medical
ISBN 13 : 9783030234195
Description :


This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.


Author : M.J.G. Harrison
Publisher : Butterworth-Heinemann
Release : 2013-10-22
Page : 656
Category : Health & Fitness
ISBN 13 : 1483182614
Description :


Contemporary Neurology compiles a large series of papers on the commonest neurological problems. This book discusses the management of epilepsy, involuntary movements, nerve and muscle diseases, and multiple sclerosis. The areas on infections, cerebrovascular disease, trauma, intracranial pressure, and vertebral column are also elaborated. This text likewise describes medical procedures on how to do a lumbar and cisternal puncture. Other topics include headache in children, hyperventilation, dizziness, funny turns—neurological, dysarthria, facial pain, and nystagmus. The weakness of the legs, loss of memory, coma, brain death, complications of alcoholism, and stupor and akinetic mutism are also covered. This publication is valuable to clinicians and examination candidates preparing for the DPM, MRCP (UK) and Neurology/Psychiatry “Boards .


Author : Natasha Pillay Smiley
Publisher : MDPI
Release : 2019-01-28
Page : 138
Category :
ISBN 13 : 3038975397
Description :


This book is a printed edition of the Special Issue "Update in Pediatric Neuro-Oncology" that was published in Bioengineering


Author : Yoshiya Yamada
Eric Chang
Publisher : Springer Nature
Release : 2020-05-30
Page : 376
Category : Medical
ISBN 13 : 303043740X
Description :


This book provides a radiotherapy perspective on the management of brain metastases with case-based discussion. This management has been rapidly evolving in the face of changing technology, progressing systemic therapy, and paradigm changes that all impact practice. These changes can be difficult, and this text gives a practical approach to help practitioners and trainees understand these changes and incorporate them into their practices. The work has two main sections: Clinical and Technical. The clinical section has chapters that address all aspects of radiation therapy for brain metastases, including integrating advances in surgery and drug treatments. The technical section focuses on the “how to” aspects of treatment, including treatment planning and delivery. This is an ideal guide for practicing radiation oncologists and trainees.


Author : Michael S. Firstenberg
Publisher : BoD – Books on Demand
Release : 2016-11-09
Page : 178
Category : Medical
ISBN 13 : 9535127691
Description :


Endocarditis remains an elusive challenge for clinicians to master. As the population ages and their comorbidities increase, the risk of infecting cardiac structures - both native and, the ever-increasing use of, prosthetic support technology - also increases. In addition, the global epidemic of intravenous substance abuse has also resulted in a substantial increase in the number of infected patients. Fortunately, advances in the diagnostic testing, imaging, and recognition of the importance of a multidisciplinary management team have also contributed to advances in the care of these critically ill patients. Nevertheless, optimal therapies need to be individualized and considered in the ever-increasing body of scientific literature on this complex and difficult problem.


Author : John A Libertino
Publisher : Springer Science & Business Media
Release : 2013-06-14
Page : 397
Category : Medical
ISBN 13 : 1461472369
Description :


Renal Cancer: Contemporary Management provides a state of the art overview of the major topics in the field of kidney cancer. The material has been collected from the most current evidence based resources to allow for the appropriate care of these patients. The sections of the book have been structured to give an overview of the major issues dealing with renal cell carcinoma and transitional cell carcinoma of the kidney. The text also reviews the new staging system, discusses familial syndromes of renal cell carcinoma, and provides new perspectives with regard to imaging and managing renal tumors. A valuable resource for physicians and researchers dealing with renal cancer, Renal Cancer: Contemporary Management provides a comprehensive summary of the field that will guide patient management and stimulate further clinical and basic science research efforts.


Author : Lizza E.L Hendriks
Deepa S. Subramaniam
Publisher : Frontiers Media SA
Release : 2019-01-21
Page : 94
Category :
ISBN 13 : 2889457079
Description :


Approximately 40% of lung cancer patients will develop central nervous system (CNS) metastases during the course of their disease. Most of these are brain metastases, but up to 10% will develop leptomeningeal metastases. Known risk factors for CNS metastases development are small cell lung cancer (SCLC), adenocarcinoma histology, epidermal growth factor receptor (EGFR) mutant or anaplastic lymphoma kinase (ALK) rearranged lung cancer, advanced nodal status, tumor stage and younger age. CNS metastases can have a negative impact on quality of life (QoL) and overall survival (OS). The proportion of lung cancer patients diagnosed with CNS metastases has increased over the years due to increased use of brain imaging as part of initial cancer staging, advances in imaging techniques and better systemic disease control. Post contrast gadolinium enhanced magnetic resonance imaging (gd-MRI) is preferred, however when this is contra-indicated a contrast enhanced computed tomography (CE-CT) is mentioned as an alternative option. When CNS metastases are diagnosed, local treatment options consist of radiotherapy (stereotactic or whole brain) and surgery. Local treatment can be complicated by symptomatic radiation necrosis for which no high level evidence based treatment exists. Moreover, differential diagnosis with metastasis progression is difficult. Systemic treatment options have expanded over the last years. Until recently, chemotherapy was the only treatment option with a poor penetration in the CNS. Angiogenesis inhibitors are promising in the treatment of primary CNS tumors as well as radiation necrosis but clinical trials of anti-angiogenic agents in NSCLC have largely excluded patients with CNS metastases. Furthermore, research has also focused on methods to prevent development of CNS disease, for example with prophylactic cranial irradiation. Recently, checkpoint inhibitors have become available for NSCLC patients, and tyrosine kinase inhibitors (TKIs) have improved prognosis significantly in those with a druggable driver mutation. Newer TKIs are often designed to have better CNS penetration compared to first-generation TKIs. Despite advances in treatment options CNS metastases remain a problem in lung cancer and cause morbidity and mortality. This Research Topic provides an extensive resource of articles describing advances in CNS metastases management in lung cancer patients, from prevention to diagnosis and treatment.


Author : Ibrahim Omerhodzic
Kenan Arnautovic
Publisher : BoD – Books on Demand
Release : 2019-01-16
Page : 258
Category : Medical
ISBN 13 : 1789849535
Description :


The past three decades have been marked with huge enthusiasm from scientists and professionals in an effort to find a cure for glioma disease. Methods to confirm the kinds and grades of glioma have taken a path from classical macro- to microscopic pathohystological confirmation of tumors, through morphological-histological, molecular, and genetic diagnosis. Surgically, progress was made possible with the development and use of technological aids, for example neuronavigation, cortical mapping, electrocorticography, neuromonitoring, functional and intraoperative MRI, magnetoencephalography, etc. Great hope was placed on the extension of tumor resection and popular supratotal resection. Significant progress has been made generally in glioma treatment with the use of modern radiotherapy and new chemotherapeutics. What do we want to see for the future? By way of stem cells, a specific medicine will be produced, individualized for the particular patient, and by using a microcapsule it will be implanted into the brain zone affected by the tumor by way of robot surgery and injection needle. This is not at all an unrealistic expectation in the next decade or two.


Author : Tracy Batchelor
Ryo Nishikawa
Publisher : Oxford University Press
Release : 2017-09-07
Page : 272
Category : Medical
ISBN 13 : 0199651876
Description :


Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Neuro-Oncology covers the pathophysiology, diagnosis, classification, and management of tumours of the nervous system. The book provides a comprehensive overview of tumour subtypes, in accordance with WHOclassifications, along with management plans for adult and paediatric populations. The international team of co-editors ensures that expert commentaries on existing and wide-reaching diagnostic and treatment guidelines (including NCCN and ESMO) are accessible by a global audience.