Genome Download Ebook PDF Epub Online

Author : Matt Ridley
Publisher : Harper Collins
Release : 2013-03-26
Page : 368
Category : Science
ISBN 13 : 0062253468
Description :


The genome's been mapped. But what does it mean? Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.


Author : Matt Ridley
Publisher : HarperCollins UK
Release : 2017-04-27
Page : 352
Category : Science
ISBN 13 : 0007381840
Description :


The most important investigation of genetic science since The Selfish Gene, from the author of the critically acclaimed and best-selling The Red Queen and The Origins of Virtue.


Author : Matt Ridley
Publisher : Harper Collins
Release : 2006-05-30
Page : 368
Category : Science
ISBN 13 : 0060894083
Description :


The genome's been mapped. But what does it mean? Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.


Author : T. Ryan Gregory
Publisher : Elsevier
Release : 2011-05-04
Page : 768
Category : Science
ISBN 13 : 9780080470528
Description :


The Evolution of the Genome provides a much needed overview of genomic study through clear, detailed, expert-authored discussions of the key areas in genome biology. This includes the evolution of genome size, genomic parasites, gene and ancient genome duplications, polypoidy, comparative genomics, and the implications of these genome-level phenomena for evolutionary theory. In addition to reviewing the current state of knowledge of these fields in an accessible way, the various chapters also provide historical and conceptual background information, highlight the ways in which the critical questions are actually being studied, indicate some important areas for future research, and build bridges across traditional professional and taxonomic boundaries. The Evolution of the Genome will serve as a critical resource for graduate students, postdoctoral fellows, and established scientists alike who are interested in the issue of genome evolution in the broadest sense. Provides detailed, clearly written chapters authored by leading researchers in their respective fields Presents a much-needed overview of the historical and theoretical context of the various areas of genomic study Creates important links between topics in order to promote integration across subdisciplines, including descriptions of how each subject is actually studied Provides information specifically designed to be accessible to established researchers, postdoctoral fellows, and graduate students alike


Author : Alessandra Gentile
Stefano La Malfa
Publisher : Springer
Release : 2020-04-24
Page : 294
Category : Science
ISBN 13 : 9783030107994
Description :


This book reviews how the release of the citrus genome facilitates the investigation of ancestral species, the study of their complex biological features, and the genetic basis of agronomic traits of paramount importance for their sustainable cultivation. The first chapters discuss citrus origin and distribution, and the economic importance and varietal composition of the cultivated species, providing an overview of citrus and related genera genetic resources. The book then describes the role of traditional breeding techniques (for scion and rootstocks) as well as the potential of genomic breeding and innovative protocols for biotechnological approaches. The second part provides essential information on the genus Citrus, the attributes of pure citrus species, genetic admixtures, hybrids and citrus relatives, and on the horticultural classification of cultivated species, varieties and rootstocks. The third part then focuses on the different molecular mechanisms, covering various aspects of citrus biology, including the role of beneficial compounds of citrus fruits. In addition, it examines the molecular responses of citrus to abiotic stresses and to field and post-harvest diseases. Providing insights gained in recent years, it is a valuable guide for those who are interested in gene discovery, comparative genomics, molecular breeding and new breeding techniques. It is particularly useful for scientists, breeders and students at universities and public sector institutes involved in research for the citrus industry.


Author : Philipp Simon
Massimo Iorizzo
Publisher : Springer
Release : 2019-05-20
Page : 372
Category : Science
ISBN 13 : 9783030033880
Description :


This book provides an up-to-date review and analysis of the carrot’s nuclear and organellar genome structure and evolution. In addition, it highlights applications of carrot genomic information to elucidate the carrot’s natural and agricultural history, reproductive biology, and the genetic basis of traits important in agriculture and human health. The carrot genome was sequenced in 2016, and its relatively small diploid genome, combined with the fact that it is the most complete root crop genome released to date and the first-ever Euasterid II genome to be sequenced, mean the carrot has an important role in the study of plant development and evolution. In addition, the carrot is among the top ten vegetables grown worldwide, and the abundant orange provitamin A carotenoids that account for its familiar orange color make it the richest crop source of vitamin A in the US diet, and in much of the world. This book includes the latest genetic maps, genetic tools and resources, and covers advances in genetic engineering that are relevant for plant breeders and biologists alike.


Author : George P. Patrinos
Publisher : Academic Press
Release : 2020-04
Page : 312
Category : Medical
ISBN 13 : 9780128178195
Description :


Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery


Author : Alexey S. Kondrashov
Publisher : John Wiley & Sons
Release : 2017-07-12
Page : 296
Category : Science
ISBN 13 : 1118952111
Description :


A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by preï¿1⁄2]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.


Author : John Quackenbush
Publisher : Charlesbridge
Release : 2011-02-01
Page : 176
Category : Science
ISBN 13 : 1607343568
Description :


The DNA sequence that comprises the human genome--the genetic blueprint found in each of our cells--is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer's, cancer, diabetes, and Parkinson's. Yet what is arguably the most important discovery of our time has also opened a Pandora's box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In the CURIOSITY GUIDE TO THE HUMAN GENOME, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease. In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliest ancestors and reconfirming our inextricable link to all life on earth. Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of the Curiosity Guides series an indispensable resource for navigating our brave new genomic world.


Author : Kate O'Riordan
Publisher : Routledge
Release : 2016-03-09
Page : 164
Category : Social Science
ISBN 13 : 1317030699
Description :


The Genome Incorporated examines the proliferation of human genomics across contemporary media cultures. It explores questions about what it means for a technoscience to thoroughly saturate everyday life, and places the interrogation of the science/media relationship at the heart of this enquiry. The book develops a number of case studies in the mediation and consumption of genomics, including: the emergence of new direct-to-the-consumer bioinformatics companies; the mundane propagation of testing and genetic information through lifestyle television programming; and public and private engagements with art and science institutions and events. Through these novel sites, this book examines the proliferating circuits of production and consumption of genetic information and theorizes this as a process of incorporation. Its wide-ranging case studies ensure its appeal to readers across the social sciences.


Author : Chittaranjan Kole
Pablo Rabinowicz
Publisher : Springer
Release : 2019-04-25
Page : 272
Category : Science
ISBN 13 : 9783319972794
Description :


This book addresses various aspects of the current castor bean research, including genetics, biotechnology, comparative genomics, and more specific topics such as oil metabolism and the ricin toxin. It also presents the whole genome sequencing of the castor bean and its impact on the mining of gene families and future plant breeding. Castor bean (Ricinus communis), an oilseed plant, belongs to the Euphorbiaceae (spurge) family. It is a tropical and subtropical crop valued for the high quality and uniform nature of its oil, which is mostly composed of the uncommon fatty acid ricinoleate. Castor bean oil has important industrial applications for the production of lubricants, cosmetics, medicines, and specialty chemicals, and castor bean has also been proposed as a biodiesel crop that does not pose concerns regarding the “food versus fuel” debate. However, it accumulates the type 2 ribosome-inactivating protein ricin in its seeds, and health concerns posed by ricin’s high toxicity have prevented broader cultivation. Recently, there has been renewed interest in castor bean due to potential biosecurity issues.


Author : Aad Tibben
Barbara B. Biesecker
Publisher : Academic Press
Release : 2019-03-30
Page : 258
Category : Medical
ISBN 13 : 0128133368
Description :


Clinical Genome Sequencing: Psychological Aspects thoroughly details key psychological factors to consider while implementing genome sequencing in clinical practice, taking into account the subtleties of genetic risk assessment, patient consent and best practices for sharing genomic findings. Chapter contributions from leading international researchers and practitioners cover topics ranging from the current state of genomic testing, to patient consent, patient responses to sequencing data, common uncertainties, direct-to-consumer genomics, the role of genome sequencing in precision medicine, genetic counseling and genome sequencing, genome sequencing in pediatrics, genome sequencing in prenatal testing, and ethical issues in genome sequencing. Applied clinical case studies support concept illustration, making this an invaluable, practical reference for this important and multifaceted topic area within genomic medicine. Features contributions from leading international researchers and practitioners versed in the psychosocial dimensions of genomic medicine implementation Presents clinical case studies that support concept illustration, making this an invaluable reference for students, researchers, and clinicians looking for practical guidance in this important and multifaceted topic area Details the current state of genomic testing, expectations of genome sequencing, patient consent, patient responses to sequencing data, uncertainties in genome sequencing, direct-to-consumer genome sequencing, and more


Author : T. A. Brown
Terence A. Brown
Publisher : Garland Science
Release : 2007
Page : 713
Category : Science
ISBN 13 : 9780815341383
Description :


The VitalBook e-book version of Genomes 3 is only available in the US and Canada at the present time. To purchase or rent please visit http://store.vitalsource.com/show/9780815341383 Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, Genomes 3is the latest edition of this pioneering textbook. Updated to incorporate the recent major advances, Genomes 3 is an invaluable companion for any undergraduate throughout their studies in molecular genetics. Genomes 3 builds on the achievements of the previous two editions by putting genomes, rather than genes, at the centre of molecular genetics teaching. Recognizing that molecular biology research was being driven more by genome sequencing and functional analysis than by research into genes, this approach has gathered momentum in recent years.


Author : National Research Council
Division on Earth and Life Studies
Publisher : National Academies Press
Release : 1988-01-01
Page : 128
Category : Science
ISBN 13 : 0309038405
Description :


There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.


Author : Fure-Chyi Chen
Publisher : Springer Nature
Release :
Page :
Category :
ISBN 13 : 3030668266
Description :



Author : David Murphy
Harold Gainer
Publisher : John Wiley & Sons
Release : 2016-01-19
Page : 488
Category : Science
ISBN 13 : 1119162181
Description :


Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems. The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today’s neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. • Written by a team of internationally renowned researchers • Both print and enhanced e-book versions are available • Illustrated in full colour throughout This is the third volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA


Author : Veli Mäkinen
Djamal Belazzougui
Publisher : Cambridge University Press
Release : 2015-05-07
Page : 413
Category : Science
ISBN 13 : 1107078539
Description :


Provides an integrated picture of the latest developments in algorithmic techniques, with numerous worked examples, algorithm visualisations and exercises.


Author : Julia E. Richards
R. Scott Hawley
Publisher : Academic Press
Release : 2010-12-12
Page : 420
Category : Science
ISBN 13 : 9780080918655
Description :


Significant advances in our knowledge of genetics were made during the twentieth century but in the most recent decades, genetic research has dramatically increased its impact throughout society. Genetic issues are now playing a large role in health and public policy, and new knowledge in this field will continue to have significant implications for individuals and society. Written for the non-majors human genetics course, Human Genetics, 3E will increase the genetics knowledge of students who are learning about human genetics for the first time. This thorough revision of the best-selling Human Genome,2E includes entirely new chapters on forensics, stem cell biology, bioinformatics, and societal/ethical issues associated with the field. New special features boxes make connections between human genetics and human health and disease. Carefully crafted pedagogy includes chapter-opening case studies that set the stage for each chapter; concept statements interspersed throughout the chapter that keep first-time students focused on key concepts; and end-of-chapter questions and critical thinking activities. This new edition will contribute to creating a genetically literate student population that understands basic biological research, understands elements of the personal and health implications of genetics, and participates effectively in public policy issues involving genetic information . Includes topical material on forensics, disease studies, and the human genome project to engage non-specialist students Full, 4-color illustration program enhances and reinforces key concepts and themes Uniform organization of chapters includes interest boxes that focus on human health and disease, chapter-opening case studies, and concept statements to engage non-specialist readers


Author : H.-W. Mewes
H. Seidel
Publisher : Springer Science & Business Media
Release : 2013-03-14
Page : 300
Category : Science
ISBN 13 : 3662047470
Description :


This book provides insight into all important fields in bioinformatics including sequence analysis, expression analysis, structural biology, proteomics and network analysis. Many of the leading scientists in the field have contributed chapters to topics of which range from genome sequence determination and its analysis, to the analysis of transcripts and proteins with the final aim of gaining a deeper understanding of the complex networks cells must obey to in order to live. The book has been compiled for the increasing number of scientists and researchers working in bioinfomatics and genome analysis worldwide who would like not only to get an overview but who also enjoy reading about the latest results in this exciting field.


Author : Xiu-Qing Li
Publisher : John Wiley & Sons
Release : 2017-04-20
Page : 448
Category : Science
ISBN 13 : 1118647122
Description :


Written by an international team of experts, Somatic Genome Variation presents a timely summary of the latest understanding of somatic genome development and variation in plants, animals, and microorganisms. Wide-ranging in coverage, the authors provide an updated view of somatic genomes and genetic theories while also offering interpretations of somatic genome variation. The text provides geneticists, bioinformaticians, biologist, plant scientists, crop scientists, and microbiologists with a valuable overview of this fascinating field of research.