Quantitative Genetics And Its Connections With Big Data And Sequenced Genomes Download Ebook PDF Epub Online

Author : Charles J Mode
Publisher : World Scientific Publishing Company
Release : 2016-11-02
Page : 180
Category :
ISBN 13 : 9813140704
Description :


The book gives an overview of developments in Quantitative Genetics and variance component analysis in an era of Big Data and Sequenced Genomes. It provides a detailed description of a direct method of estimation that will be a useful means of extracting information from a large set of data that was inconceivable 10 to 20 years ago. The book is a combination of a history of variance component analysis and a forward looking view as to how direct methods of estimation arise from the availability of big data sets and sequenced genomes of each individual in the sample. Many papers and books on quantitative genetics versions of the general linear model from statistics are useful for analyzing the data, using relatively small sets of data. In this book, new methods of direct estimation are introduced and analyzed that are appropriate for an era of big sets of data and sequences genomes. These direct methods of estimation are based on taking conditional expectations rather the methods of least squares that characterize many applications of the general linear model of statistics. Request Inspection Copy


Author : Colin J. Sanderson
Publisher : World Scientific
Release : 2007
Page : 345
Category : Science
ISBN 13 : 9812703756
Description :


The rapid progress in genomics and related technologies has increased interest in genetically modified organisms (GMOs). This book equips you with information about what genes are, how they work, and how they can be modified and used in biotechnology. On environmental genetics, it also considers the risks of releasing agricultural GM plants.


Author : National Research Council
Division on Earth and Life Studies
Publisher : National Academies Press
Release : 2007-06-24
Page : 170
Category : Science
ISBN 13 : 0309106761
Description :


Although we can't usually see them, microbes are essential for every part of human life -- indeed all life on Earth. The emerging field of metagenomics offers a new way of exploring the microbial world that will transform modern microbiology and lead to practical applications in medicine, agriculture, alternative energy, environmental remediation, and many others areas. Metagenomics allows researchers to look at the genomes of all of the microbes in an environment at once, providing a "meta" view of the whole microbial community and the complex interactions within it. It's a quantum leap beyond traditional research techniques that rely on studying -- one at a time -- the few microbes that can be grown in the laboratory. At the request of the National Science Foundation, five Institutes of the National Institutes of Health, and the Department of Energy, the National Research Council organized a committee to address the current state of metagenomics and identify obstacles current researchers are facing in order to determine how to best support the field and encourage its success. The New Science of Metagenomics recommends the establishment of a "Global Metagenomics Initiative" comprising a small number of large-scale metagenomics projects as well as many medium- and small-scale projects to advance the technology and develop the standard practices needed to advance the field. The report also addresses database needs, methodological challenges, and the importance of interdisciplinary collaboration in supporting this new field.


Author : Matt Ridley
Publisher : Harper Collins
Release : 2013-03-26
Page : 368
Category : Science
ISBN 13 : 0062253468
Description :


The genome's been mapped. But what does it mean? Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.


Author : Philipp Simon
Massimo Iorizzo
Publisher : Springer
Release : 2019-05-08
Page : 372
Category : Science
ISBN 13 : 3030033899
Description :


This book provides an up-to-date review and analysis of the carrot’s nuclear and organellar genome structure and evolution. In addition, it highlights applications of carrot genomic information to elucidate the carrot’s natural and agricultural history, reproductive biology, and the genetic basis of traits important in agriculture and human health. The carrot genome was sequenced in 2016, and its relatively small diploid genome, combined with the fact that it is the most complete root crop genome released to date and the first-ever Euasterid II genome to be sequenced, mean the carrot has an important role in the study of plant development and evolution. In addition, the carrot is among the top ten vegetables grown worldwide, and the abundant orange provitamin A carotenoids that account for its familiar orange color make it the richest crop source of vitamin A in the US diet, and in much of the world. This book includes the latest genetic maps, genetic tools and resources, and covers advances in genetic engineering that are relevant for plant breeders and biologists alike.


Author : Jialiang Yang
Liao Bo
Publisher : Frontiers Media SA
Release : 2020-02-27
Page :
Category :
ISBN 13 : 2889635287
Description :



Author : Ka-Chun Wong
Publisher : Springer
Release : 2016-10-24
Page : 428
Category : Computers
ISBN 13 : 3319412795
Description :


This contributed volume explores the emerging intersection between big data analytics and genomics. Recent sequencing technologies have enabled high-throughput sequencing data generation for genomics resulting in several international projects which have led to massive genomic data accumulation at an unprecedented pace. To reveal novel genomic insights from this data within a reasonable time frame, traditional data analysis methods may not be sufficient or scalable, forcing the need for big data analytics to be developed for genomics. The computational methods addressed in the book are intended to tackle crucial biological questions using big data, and are appropriate for either newcomers or veterans in the field.This volume offers thirteen peer-reviewed contributions, written by international leading experts from different regions, representing Argentina, Brazil, China, France, Germany, Hong Kong, India, Japan, Spain, and the USA. In particular, the book surveys three main areas: statistical analytics, computational analytics, and cancer genome analytics. Sample topics covered include: statistical methods for integrative analysis of genomic data, computation methods for protein function prediction, and perspectives on machine learning techniques in big data mining of cancer. Self-contained and suitable for graduate students, this book is also designed for bioinformaticians, computational biologists, and researchers in communities ranging from genomics, big data, molecular genetics, data mining, biostatistics, biomedical science, cancer research, medical research, and biology to machine learning and computer science. Readers will find this volume to be an essential read for appreciating the role of big data in genomics, making this an invaluable resource for stimulating further research on the topic.


Author : Eugene J Eisen
Publisher : World Scientific
Release : 2005-06-27
Page : 376
Category : Science
ISBN 13 : 1783260262
Description :


The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields. Chapter 1: The Beginnings - Ode To A Wee Mouse (58 KB) Contents:The Beginnings: Ode to a Wee Mouse (E J Eisen)Testing Quantitative Genetic Selection Theory (E J Eisen)Maternal Effects, Genomic Imprinting and Evolution (J Funk-Keenan & W R Atchley)Inbreeding and Crossbreeding (G A Brockmann)Genotype by Environment Interaction: Lessons From the Mouse (W D Hohenboken)Genetics of Growth in the Mouse (J M Cheverud)Genetics of Body Composition and Metabolic Rate (L Bünger & W G Hill)Genetics of Reproduction (M K Nielsen)Genetics of Behavior (R J Hitzemann)Genetics of Disease Resistance (S L Ewart & R A Ramadas)Genomic Dissection of Complex Trait Predisposition (D Pomp)Mouse Mutagenesis (D R Beier)Embryo Biotechnologies (C A Pinkert & M J Martin)Transgenics (J D Murray & E A Maga)The Mouse in Biomedical Research (R B Roberts & D W Threadgill)The Mouse Genome Sequencing Project: An Overview (M C Wendl et al.) Readership: Researchers, teachers, graduate students and advanced undergraduates in genetics, genomics, biotechnology, bioinformatics, animal breeding and zoology. Key Features:Covers the methods used to find genes in the mouse that affect complex genetic traitsCuts across biomedical and bioagricultural applicationsNo competing titles availableKeywords:Genetics;Mouse;Biotechnology;Genome Sequencing;Quantitative Genetics;Transgenics;Growth;Reproduction;Biomedical Genetics;Biomedical Genetics;Behavior;Maternal Genetics;ENU Mutagenesis


Author : Claude Bouchard
Robert M. Malina
Publisher : Human Kinetics
Release : 1997
Page : 400
Category : Science
ISBN 13 : 9780873229517
Description :


Genetics of Fitness and Physical Performance is the first comprehensive reference on the role of the genes in influencing individual variation in fitness and performance. This essential compendium reviews the past 25 years of accumulated evidence on the genetic basis of health- and performance-related fitness phenotypes. Focusing on the interests of sport scientists, the authors provide insight into the significance of this research on nearly every aspect of the study of human physical activity. The book presents the biological basis of heredity and explains the concepts and methods of genetic epidemiology and molecular biology that are necessary to understand this specialized field. With the rapid advances in molecular biology and the paradigms of human genetics, exercise scientists face a dynamic and vibrant new field. This book offers readers new opportunities to better understand atherosclerosis, noninsulin dependent diabetes, obesity, and hypertension by searching for single gene effects and identifying susceptibility genes. The authors review the evidence on the role of the genes for human traits as it pertains to the exercise science field. And they explore the scientific, practical, and ethical issues that confront exercise scientists as progress is made in this field. Genetics of Fitness and Physical Performance is vital reading for scholars in the field of exercise and sport science to understand how recent discoveries in genetics might shape their future research.


Author : National Research Council
Institute of Medicine
Publisher : National Academies Press
Release : 2006-06-07
Page : 316
Category : Science
ISBN 13 : 9780309164757
Description :


Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways--leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are generating breakthroughs in the life sciences and related technologies. The risks posed by bioterrorism and the proliferation of biological weapons capabilities have increased concern about how the rapid advances in genetic engineering and biotechnology could enable the production of biological weapons with unique and unpredictable characteristics. Globalization, Biosecurity, and the Future of Life Sciences examines current trends and future objectives of research in public health, life sciences, and biomedical science that contain applications relevant to developments in biological weapons 5 to 10 years into the future and ways to anticipate, identify, and mitigate these dangers.


Author : WHO
World Health Organization
Publisher : World Health Organization
Release : 2004-07-23
Page : 209
Category : Law
ISBN 13 : 9241580356
Description :


The Global Status Report on Alcohol 2004 is a new edition of the Report published by WHO in 1999. This edition provides an update of the role of alcohol in global health and contains data not found in the earlier edition. The Report seeks to document what is known about alcohol consumption and drinking patterns among various population groups, alcohol's impact on health worldwide and what is needed on a global basis to prevent and reduce alcohol-related injury and disease. For this new edition, more emphasis has been placed on enhancing the comparability of data by setting clear and comprehens.


Author : Girard, John
Publisher : IGI Global
Release : 2015-02-28
Page : 312
Category : Business & Economics
ISBN 13 : 1466681233
Description :


The ability to uncover, share, and utilize knowledge is one of the most vital components to the success of any organization. While new technologies and techniques of knowledge dissemination are promising, there is still a struggle to derive and circulate meaningful information from large data sets. Strategic Data-Based Wisdom in the Big Data Era combines the latest empirical research findings, best practices, and applicable theoretical frameworks surrounding data analytics and knowledge acquisition. Providing a multi-disciplinary perspective of the subject area, this book is an essential reference source for professionals and researchers working in the field of knowledge management who would like to improve their understanding of the strategic role of data-based wisdom in different types of work communities and environments.


Author : Charles J. Mode
Candace K. Sleeman
Publisher : World Scientific
Release : 2000
Page : 739
Category : Science
ISBN 13 : 981024097X
Description :


AIDS (autoimmune deficiency syndrome) is a devastating human disease cause by HIV, a human immunodeficiency virus, which may be transmitted by either sexual or other contacts in which body fluids are exchanged. Cases of AIDS have been reported in a majority of countries throughout the world, indicating that the HIV/AIDS epidemic is international in scope. This book deals with the mathematical and statistical techniques underlying the models used to understand the population dynamics of not only HIV/AIDS but also other infectious diseases. Attention is given to the development strategies for the prevention and control of the international epidemic within the frameworks of the models. Two distinguishing features of the book are the incorporation of stochastic and deterministic formulations within a unifying conceptual framework and the discussion of issues related to the mathematical designs of models, which are necessary for the rigorous utilization of computer-intensive methods. The book will be of value to applied mathematicians, biomathematicians, biostatisticians, epidemiologists and other scientists interested in applying mathematics and computers to not only the HIV/AIDS epidemic but also other fields of epidemiology.


Author : Ian Korf
Mark Yandell
Publisher : "O'Reilly Media, Inc."
Release : 2003-07-29
Page : 339
Category : Computers
ISBN 13 : 0596002998
Description :


This is the only book completely devoted to the popular BLAST (Basic Local Alignment Search Tool), and one that every biologist with an interest in sequence analysis should learn from.


Author : Tarun Weeramanthri
Hugh Dawkins
Publisher : Frontiers Media SA
Release : 2018-06-25
Page :
Category :
ISBN 13 : 2889455017
Description :


Precision Public Health is a new and rapidly evolving field, that examines the application of new technologies to public health policy and practice. It draws on a broad range of disciplines including genomics, spatial data, data linkage, epidemiology, health informatics, big data, predictive analytics and communications. The hope is that these new technologies will strengthen preventive health, improve access to health care, and reach disadvantaged populations in all areas of the world. But what are the downsides and what are the risks, and how can we ensure the benefits flow to those population groups most in need, rather than simply to those individuals who can afford to pay? This is the first collection of theoretical frameworks, analyses of empirical data, and case studies to be assembled on this topic, published to stimulate debate and promote collaborative work.


Author : Ibrokhim Y. Abdurakhmonov
Publisher : BoD – Books on Demand
Release : 2016-07-27
Page : 268
Category : Science
ISBN 13 : 953512546X
Description :


An interdisciplinary bioinformatics science aims to develop methodology and analysis tools to explore large-volume of biological data using conventional and modern computer science, statistics, and mathematics, as well as pattern recognition, reconstruction, machine learning, simulation and iterative approaches, molecular modeling, folding, networking, and artificial intelligence. Written by international team of life scientists, this Bioinformatics book provides some updates on bioinformatics methods, resources, approaches, and genome analysis tools useful for molecular sciences, medicine and drug designs, as well as plant sciences and agriculture. I trust chapters of this book should provide advanced knowledge for university students, life science researchers, and interested readers on some latest developments in the bioinformatics field.


Author : Ben Hui Liu
Publisher : CRC Press
Release : 2017-11-22
Page : 648
Category : Mathematics
ISBN 13 : 1351414534
Description :


Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.


Author : Ioannis Nezis
Sovan Sarkar
Publisher : Frontiers Media SA
Release : 2020-02-10
Page :
Category :
ISBN 13 : 2889634825
Description :



Author : Eugene V. Koonin
Publisher : FT Press
Release : 2011-06-23
Page : 528
Category : Science
ISBN 13 : 9780132623179
Description :


The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and hypotheses on the key aspects of the evolution of life on earth in light of comparative genomics and systems biology. The author presents many specific examples from systems and comparative genomic analysis to begin to build a new, much more detailed, complex, and realistic picture of evolution. The book examines a broad range of topics in evolutionary biology including the inadequacy of natural selection and adaptation as the only or even the main mode of evolution; the key role of horizontal gene transfer in evolution and the consequent overhaul of the Tree of Life concept; the central, underappreciated evolutionary importance of viruses; the origin of eukaryotes as a result of endosymbiosis; the concomitant origin of cells and viruses on the primordial earth; universal dependences between genomic and molecular-phenomic variables; and the evolving landscape of constraints that shape the evolution of genomes and molecular phenomes. "Koonin's account of viral and pre-eukaryotic evolution is undoubtedly up-to-date. His "mega views" of evolution (given what was said above) and his cosmological musings, on the other hand, are interesting reading." Summing Up: Recommended Reprinted with permission from CHOICE, copyright by the American Library Association.


Author : Aravinda Chakravarti
Eric Green
Publisher :
Release : 2012-09-01
Page : 469
Category : Science
ISBN 13 : 9780824337131
Description :