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Author : Brittany Kaiser
Publisher : HarperCollins
Release : 2019-10-22
Page : 400
Category : Political Science
ISBN 13 : 0062965808
Description :


In this explosive memoir, a political consultant and technology whistleblower reveals the disturbing truth about the multi-billion-dollar data industry, revealing to the public how companies are getting richer using our personal information and exposing how Cambridge Analytica exploited weaknesses in privacy laws to help elect Donald Trump—and how this could easily happen again in the 2020 presidential election. When Brittany Kaiser joined Cambridge Analytica—the UK-based political consulting firm funded by conservative billionaire and Donald Trump patron Robert Mercer—she was an idealistic young professional working on her fourth degree in human rights law and international relations. A veteran of Barack Obama’s 2008 campaign, Kaiser’s goal was to utilize data for humanitarian purposes, most notably to prevent genocide and human rights abuses. But her experience inside Cambridge Analytica opened her eyes to the tremendous risks that this unregulated industry poses to privacy and democracy. Targeted is Kaiser’s eyewitness chronicle of the dramatic and disturbing story of the rise and fall of Cambridge Analytica. She reveals to the public how Facebook’s lax policies and lack of sufficient national laws allowed voters to be manipulated in both Britain and the United States, where personal data was weaponized to spread fake news and racist messaging during the Brexit vote and the 2016 election. But the damage isn’t done Kaiser warns; the 2020 election can be compromised as well if we continue to do nothing. In the aftermath of the U.S. election, as she became aware of the horrifying reality of what Cambridge Analytica had done in support of Donald Trump, Kaiser made the difficult choice to expose the truth. Risking her career, relationships, and personal safety, she told authorities about the data industry’s unethical business practices, eventually testifying before Parliament about the company’s Brexit efforts and helping Special Counsel Robert Mueller’s investigation into Russian interference in the 2016 election, alongside at least 10 other international investigations. Packed with never-before-publicly-told stories and insights, Targeted goes inside the secretive meetings with Trump campaign personnel and details the promises Cambridge Analytica made to win. Throughout, Kaiser makes the case for regulation, arguing that legal oversight of the data industry is not only justifiable but essential to ensuring the long-term safety of our democracy. Targeted includes 20-30 photos.


Author : Stephen Hunter
Publisher : Simon and Schuster
Release : 2022-01-18
Page : 384
Category : Fiction
ISBN 13 : 1982169796
Description :


"After being accused of reckless endangerment and forced to answer to the U.S. Congress, master sniper Bob Lee Swagger must protect political hostages in a once-in-a-lifetime standoff"--


Author : Zuhair Kashmeri
Brian McAndrew
Publisher : James Lorimer & Company
Release : 2005-09-06
Page : 158
Category : History
ISBN 13 : 9781550289046
Description :


A provocative look at one of Canada's biggest tragedies On March 16, 2005, almost twenty years after one of the biggest mass murders in Canadian Aviation history, the Air-India Case concluded with a verdict that authors Zuhair Kashmeri and Brian McAndrew predicted sixteen years ago when Soft Target was first published: not guilty. In this second edition, the two offer a detailed foreword that brings readers up-to-date with some startling new information surrounding the twin bombings on June 23, 1985 in the air over the Atlantic, and on the ground in Japan, which left 331 people dead. They offer key details from the trial of Ripudaman Singh Malik and Ajaib Singh Bagri that took place in a specially-built Vancouver courtroom, leads that were not followed up, and more details of India's intelligence service's clandestine interference in Canada. They explain how their own prediction that justice would not be found because of a botched investigation came true, and that only a public inquiry will offer closure to the families of the victims.


Author : Randal Hojem Eckert
Publisher :
Release : 2006
Page : 306
Category :
ISBN 13 :
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Author : Robert Pollin
Mwangi wa Gĩthĩnji
Publisher : Edward Elgar Pub
Release : 2008
Page : 274
Category : Business & Economics
ISBN 13 :
Description :


Contents: Brief Highlights of Major Proposals Summary of Major Findings and Proposals 1. Introduction 2. Employment Conditions and Living Standards 3. Profile of Non-agricultural Household Enterprises 4. Labor Costs, Labor Market Institutions and Employment Expansion 5. The Rural Sector: Institutional Reform for Development 6. Investing in Roads and Water Infrastructure 7. Monetary Policy, Inflation Control, and Interest Rates 8. Exchange Rate Policy and Foreign Trade 9. Restructuring Kenya's Financial System 10. Fiscal Policy: How to Pay for New Pro-employment Initiatives 11. A Restatement of Goals and Strategies Appendix 1: Earnings Function for Household Enterprises Appendix 2: Supply Shock Inflation Appendix 3: Exchange Rate Overvaluation Model Acronyms Bibliography Index


Author : Christopher J. O'Leary
Publisher :
Release : 2003
Page : 18
Category : Unemployed
ISBN 13 :
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Author : Sarita Surendra Naik
Publisher :
Release : 2004
Page :
Category :
ISBN 13 :
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Author : Christina Diaz Gonzalez
Publisher : Scholastic Inc.
Release : 2016-09-27
Page : 224
Category : Juvenile Fiction
ISBN 13 : 0545773245
Description :


WHO WILL CONTROL DESTINY? Cassie Arroyo has the ability to use the Spear of Destiny. And despite knowing the dangers of such a powerful object, she uses it to shape the future and save her father's life. The consequences of that small choice are larger than Cassie could ever have imagined. It produced a chain reaction - and now, in her visions of the future, Cassie sees chaos and death spreading across Rome. With the help of her friend Asher, Cassie is determined to fix the future she's created . . . but it's not going to be simple. The spear's been stolen by people who want to use it for their own dark purposes. Can Cassie recapture the spear before it's used against her? And will she be able to undo the harm she's caused, or will she only cast the world into greater chaos? Christina Diaz Gonzalez's Return Fire is a nonstop, action-packed adventure, full of mystery and intrigue, that will take you on a wild and wonderful ride across Italy.


Author : Christina Diaz Gonzalez
Publisher : Scholastic Inc.
Release : 2015-08-25
Page : 256
Category : Juvenile Fiction
ISBN 13 : 0545773202
Description :


Cassie Arroyo, an American studying in Rome, has her world ripped apart when someone tries to kill her father, an art history professor at an Italian university. Is she their next target? Cassie sets out to uncover what is happening, only to learn that she is a member of an ancient bloodline that enables her to use the Spear of Destiny--a legendary object that can alter the future. Now running from a secret organization intent on killing those from her bloodline, Cassie must--with the help of some friends--decipher the clues that will lead her to the Spear. Christina Diaz Gonzalez has created a fast-paced thrill-ride of a book, rich with riddles and myth, that young readers will not want to put down.


Author : Paul Brennan
Saleta Vazquez-Rodriguez
Publisher : Royal Society of Chemistry
Release : 2020-11-25
Page : 320
Category : Science
ISBN 13 : 1788015894
Description :


Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.


Author : Rodney Scott
Ross Boyd
Publisher : Brookings Institution Press
Release : 2022-03-08
Page : 320
Category : Political Science
ISBN 13 : 0815739192
Description :


New Zealand’s deceptively simple but effective program to improve public services New Zealand has long been considered at the forefront of public administration, experimenting with new ways of organizing and delivering public services. Even so, successive New Zealand governments had mixed results from using traditional public management tools to lift the performance of the public service and address persistent problems that required multi-agency action. In 2012 the government decided to try something different. As part of a reform package called Better Public Services, the government challenged the public service to organize itself around achieving just ten results that had proven resistant to previous interventions. The plan was deceptively simple: set ambitious targets and publicly report on progress every six months; hold small groups of public managers collectively responsible; use lead indicators; and learn from both success and failure. This book explores how and why the New Zealand government made progress and how the program was able to create and sustain the commitment of public servants and unleash the creativity of public entrepreneurs. The authors combine case studies based on the experience of people involved in the change, together with public management research. They explain how ambitious targets and public accountability were used as levers to overcome the bureaucratic barriers that impeded public service delivery, and how data, evidence, and innovation were used to change practice. New Zealand experimented, failed, succeeded, and learned from the experience over five years. This New Zealand experience demonstrates that interagency performance targets are a potentially powerful tool for fostering better public services and thus improving social outcomes.


Author : Markus Gunneflo
Publisher : Cambridge University Press
Release : 2016-05-12
Page :
Category : Law
ISBN 13 : 1316552845
Description :


Looking beyond the events of the second intifada and 9/11, this book reveals how targeted killing is intimately embedded in both Israeli and US statecraft, and in the problematic relationship between sovereign authority and lawful violence underpinning the modern state system. It details the legal and political issues raised in targeted killing as it has emerged in practice, including questions of domestic constitutional authority, the use of force in international law, the law of belligerent occupation, the law of targeting and human rights law. The distinctive nature of Israeli and US targeted killing is analysed in terms of the compulsion of legality characteristic of the liberal constitutional state, a compulsion that demands the ability to distinguish between legal 'targeted killing' and extra-legal 'political assassination'. The effect is a highly legalized framework for the extraterritorial killing of designated terrorists that may significantly affect the international law of force.


Author : Richard M. Schultz
Publisher : Springer Science & Business Media
Release : 2006-01-24
Page : 303
Category : Medical
ISBN 13 : 3764374144
Description :


There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.


Author : Ann L. Jackman
Christopher P. Leamon
Publisher : Springer Science & Business Media
Release : 2011-05-05
Page : 254
Category : Medical
ISBN 13 : 1441984178
Description :


Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.


Author : United States. General Accounting Office
Publisher :
Release : 1991
Page : 34
Category : Employees
ISBN 13 :
Description :



Author : Prashant Kesharwani
Umesh Gupta
Publisher : Academic Press
Release : 2018-04-20
Page : 478
Category : Medical
ISBN 13 : 0128122498
Description :


Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors


Author : Yashwant Pathak
Nazrul Islam
Publisher : CRC Press
Release : 2021-10-17
Page : 692
Category : Medical
ISBN 13 : 1000450767
Description :


Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems


Author : Vladimir P. Torchilin
Publisher : CRC Press
Release : 1995-08-23
Page : 752
Category : Medical
ISBN 13 : 9780849383083
Description :


This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.


Author :
Publisher : Teacher Created Materials
Release : 2012-04-15
Page :
Category :
ISBN 13 : 9781433339905
Description :



Author : Renee Pittman
Publisher : Mother's Love Publishing and Enterprises
Release : 2014-03-31
Page :
Category : Science
ISBN 13 :
Description :


The key to the success of weaponized beamed technology derived from the Electromagnetic Spectrum depends on several factors. One of the most successful is the strategic effort to discredit victims by applying the mental illness tag and hoping it will stick. For success, the use of anyone around victims, especially family members become crucial. Renee Pittman continues her mission of exposing the hidden evil today by pulling back the shroud of secrecy. This is not only done through the testimony of professionals and compiled open literature evidence but through her personal experiences and the testimony of victims both men, women, and even children, confirming legalized, ongoing human experimentation on steroids. In a diary-like setting, the author gives explicit details of her continued, day-to-day battle, to combat covert technological terrorism. She details the continued hope of many for justice system intervention and coping with the roadblocks faced as an inability to effectively litigate against a Goliath, in these cases, high-powered government agencies of the United States of America. Sadly, many attorneys will not touch these difficult to prove cases, due to the invisible beamed weapons being used. As a result, thousands of lives are being destroyed without recourse. However, to the dismay of those seeking to keep the widespread use of advanced psychotronic technology under wraps and its capabilities, Pittman details, not only its machination but also provides excellent examples of precise, heinous, manipulative techniques, for example, the creation of sexual deviance as well, as a means of controlling targets and even blackmailing into submission. With the focus on women, many report covert efforts to turn women into sex slaves by the men of depraved minds who are some of the more perverse at the helm of these advancements. The battle to bring the truth before the public continues with the assurance that the truth will ultimately prevail and inevitably always has!