The Common Marmoset In Captivity And Biomedical Research Download Ebook PDF Epub Online

Author : Robert P. Marini
Lynn M. Wachtman
Publisher : Academic Press
Release : 2018-11-19
Page : 570
Category : Science
ISBN 13 : 012811830X
Description :


The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series


Author : National Academies of Sciences, Engineering, and Medicine
Division on Earth and Life Studies
Publisher : National Academies Press
Release : 2019-08-26
Page : 122
Category : Science
ISBN 13 : 0309488516
Description :


The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.


Author : Joerg Bluemel
Sven Korte
Publisher : Academic Press
Release : 2015-03-13
Page : 716
Category : Medical
ISBN 13 : 012417146X
Description :


The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes


Author : Sarah Wolfensohn
Paul Honess
Publisher : John Wiley & Sons
Release : 2008-04-15
Page : 176
Category : Medical
ISBN 13 : 1405156155
Description :


Handbook of Primate Husbandry and Welfare covers all aspects of primate care and management both in the laboratory environment and in zoos. From the welfare and ethics of primate captivity through to housing and husbandry systems, environmental enrichment, nutritional requirements, breeding issues, primate diseases, and additional information on transportation and quarantine proceedings, this book provides a completely comprehensive guide to good husbandry and management of primates. Designed to be a practical field manual, the authors present the material using lists, tables and illustrations to clarify best practice. Representative species are covered – from marmosets through to macaques One of the first books dedicated to the care of primates in captivity Written by authors with many years of experience working with primates Suitable for those working with primates in either laboratories or zoos


Author : National Research Council
Division on Earth and Life Studies
Publisher : National Academies Press
Release : 2003-03-01
Page : 306
Category : Technology & Engineering
ISBN 13 : 0309069890
Description :


This new release presents the wealth of information gleaned about nonhuman primates nutrition since the previous edition was published in 1978. With expanded coverage of natural dietary habits, gastrointestinal anatomy and physiology, and the nutrient needs of species that have been difficult to maintain in captivity, it explores the impact on nutrition of physiological and life-stage considerations: infancy, weaning, immune function, obesity, aging, and more. The committee also discusses issues of environmental enrichment such as opportunities for foraging. Based on the world's scientific literature and input from authoritative sources, the book provides best estimates of nutrient requirements. The volume covers requirements for energy: carbohydrates, including the role of dietary fiber; proteins and amino acids; fats and fatty acids; minerals, fat-soluble and water-soluble vitamins; and water. The book also analyzes the composition of important foods and feed ingredients and offers guidelines on feed processing and diet formulation.


Author : Gene P. Sackett
Gerald Ruppenthal
Publisher : Springer Science & Business Media
Release : 2010-05-10
Page : 602
Category : Medical
ISBN 13 : 9780387256405
Description :


Nursery Rearing of Nonhuman Primates in the 21st Century describes how and why nursery rearing of primates can produce adaptable juveniles and adults for research, conservation, and display-educational purposes. The volume details the history of nursery rearing since the mid-19th century, the outcomes of varied nursery rearing methods, the contemporary goals of nursery rearing as well as reference data derived from species commonly reared in nursery or hand-feeding situations. Examples of the changing goals of nursery rearing covered in this volume are the need for biological containment in disease research, the production of specific pathogen-free colonies by removal of neonates from the mother, the production of phenotypes for genetic and molecular biology studies, and the breeding of endangered species for conservation or research purposes.


Author : H.O. Box
Publisher : Springer Science & Business Media
Release : 2012-12-06
Page : 442
Category : Science
ISBN 13 : 9401131104
Description :


This book concerns the various ways that primates respond to environmental change. By studying these patterns of responsiveness we not only gain useful knowledge about the structural, physiological and behavioural propensities of different species, but also acquire important information relating to issues of contemporary concern, such as conservation and the management of animals in the wild as well as in various forms of captivity. For example, there is growing concern among biologists and conser vationists about the influence of habitat destruction, such as logging, on the fitness and survival of wild primates. There is also increased awareness of the need to improve the care of primates in zoos and laboratories, including the enrichment of captive environments. Further, because an increasing number of primate species are becom ing endangered, knowledge of their responsiveness to new environ ments is an essential requirement for effective breeding programmes in captivity, and for the translocation and rehabilitation of species in the wild. In theory, studies of many closely related species are required in order to consider relevant evolutionary processes, as well as to develop functional hypotheses about the adaptive significance of various biological propensities and their interrelationships in the short and longer terms.


Author : J.P. Hearn
Publisher : Springer Science & Business Media
Release : 2012-12-06
Page : 224
Category : Medical
ISBN 13 : 9400973225
Description :


The New World primates are becoming widely used in scientific and medical work in fields from anthropology to zoology, behaviour to urology. They have unique attributes for studies in cancer, infectious diseases, genetics, virology and reproduction. However, it is only now that their reproductive physiology is being clarified in any depth and this book is a first synthesis of that knowledge. The nine authors involved in this project have presented an up to date account of the major New World species used in biological and medical science. In addition to their distribution and conservation in the wild, essential biological data from laboratory studies are presented on reproductive cycles, gestation length, seasonal breeding, puberty and other factors. The major applications of these species in research are explored. Whenever possible, research workers should steer away from using endangered species in their studies. The New World monkeys used in research in any numbers are still fairly common ~n the wild, yet their greatest advantages are ~n their smalle size and high fecundity. This makes possible the establishment of self sustaining captive breeding colonies at a fraction of the time and cost necessary for the more conventional Old World laboratory primates. Consequently the drain on wild stocks need not be extensive as only breeding nuclei should be necessary.


Author : National Research Council
Division on Earth and Life Studies
Publisher : National Academies Press
Release : 2006-08-14
Page : 164
Category : Science
ISBN 13 : 0309101107
Description :


Arranging the transportation of animals at research facilities is often an ordeal. There is a confusing patchwork of local, national, and international regulations; a perceived lack of high-quality shipping services; a dearth of science-based good practices; and a lack of biosafety standards. It's a challenge â€"and an impediment to biomedical research. Guidelines for the Humane Transportation of Research Animals identifies the current problems encountered in the transportation of research animals and offers recommendations aimed at local and federal officials to rectify these problems. This book also includes a set of good practices based on the extensive body of literature on transportation of agricultural animals, universal concepts of physiology, and a scientific understanding of species-specific needs and differences. Good practices were developed by the committee to address thermal environment, space requirements, food and water requirements, social interaction, monitoring of transportation, emergency procedures, personnel training, and biosecurity. Guidelines for the Humane Transportation of Research Animals is an essential guide for all researchers, animal care technicians, facilities managers, administrators, and animal care and use committees at research institutions.


Author : Dorte Bratbo Sørensen
Sylvie Cloutier
Publisher : CRC Press
Release : 2020-10-14
Page : 190
Category : Medical
ISBN 13 : 0429602057
Description :


The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and management, Animal-centric Care and Management: Enhancing Refinement in Biomedical Research takes Russell and Burch’s definition of Refinement as "elimination of inhumanities" and goes further. Rather than fitting animals into experimental conditions, it encourages readers to adjust conditions to better meet the behavioral, emotional, physical, and physiological needs and preferences of the animals. The team of expert authors, from the fields of laboratory animal science, ethology, biology as well as animal training, provide ideas for creating housing conditions and handling procedures that induce, to the best of current abilities and knowledge, a long-term positive state of mind in the animals under our care. This book is written for animal caretakers, animal health technicians, researchers, animal facility managers, laboratory animal veterinarians, and anyone who engages in work with living experimental animals or is interested in the continuous improvement of laboratory animal welfare. This interdisciplinary guide will act as a catalyst, resulting in multiple viewpoints and fields collaborating to optimize laboratory animal welfare.


Author : Margi Sirois
Publisher : Mosby
Release : 2005
Page : 350
Category : Medical
ISBN 13 :
Description :


This combination text and lab manual provides clinically relevant coverage of laboratory animal medicine and procedures. It covers a variety of species, including rats, mice, guinea pigs, hamsters, rabbits, gerbils, ferrets, nonhuman primates, and in a separate chapter, nontraditional lab animals, such as swine, chinchillas, armadillos, reptiles, amphibians, bats, farm animals, and dogs and cats. Coverage of each species is presented in a consistent format that includes taxonomy, anatomy and physiology, uses in biomedical research, reproduction, behavior, husbandry, restraint and handling, identification methods, injection techniques, medication administration and anesthesia, blood collection, common diseases, and euthanasia. Other key topics include the laboratory setting, regulatory guidelines, and ethical considerations. The lab manual portion of the book features a variety of exercises and observation sheets. Comprehensive coverage of a variety of topics such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations prepares readers for a career in laboratory animal medicine Familiarizes readers with the handling, behavior, nutrition, and lab and treatment procedures for a large variety of common and nontraditional laboratory animals The consistent organization of each species chapter makes it easy for readers to quickly identify similarities and differences among various laboratory animals Laboratory exercises are included in a perforated section at the end of the book, allowing users to apply their knowledge and develop job skills Features a wealth of user-friendly features such as a two-color design, learning objectives, key points, and review questions Provides detailed information on specific legal and ethical requirements of lab animal care and use, including the ethics of pain management Convenient boxes and tables provide quick access to important anatomic and physiologic data for each species Discusses specific uses of each species in biomedical research, providing readers with a perspective on animal use that allows them to explain the benefits of animal use as required by veterinary technology program accreditation procedures


Author : National Research Council
Division on Earth and Life Studies
Publisher : National Academies Press
Release : 2003-07-13
Page : 180
Category : Science
ISBN 13 : 030908914X
Description :


The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a flexible and comprehensive Occupational Health and Safety Program (OHSP) that can identify and mitigate potential hazards. Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools necessary for informed decision-making in developing an optimal program that meets all particular institutional needs.


Author :
Publisher : Elsevier
Release : 2005-09-19
Page : 650
Category : Science
ISBN 13 : 9780080454160
Description :


A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included. Two-color, user-friendly format, with copious illustrations and color plates Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques


Author :
Publisher : Elsevier
Release : 1998-07-24
Page : 512
Category : Medical
ISBN 13 : 9780080537634
Description :


This volume and its companion Nonhuman Primates in Biomedical Research: Biology and Management represent the most comprehensive publications of their type on nonhuman primates. This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management. Its companion volume serves as a general reference for those who provide care for these animals and for those who use them in biomedical research.


Author : National Research Council
Division on Earth and Life Studies
Publisher : National Academies Press
Release : 2011-09-16
Page : 42
Category : Science
ISBN 13 : 030921954X
Description :


The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.


Author : Doris Schroeder
Julie Cook
Publisher : Springer
Release : 2017-12-04
Page : 134
Category : Philosophy
ISBN 13 : 3319647318
Description :


This open access book provides original, up-to-date case studies of “ethics dumping” that were largely facilitated by loopholes in the ethics governance of low and middle-income countries. It is instructive even to experienced researchers since it provides a voice to vulnerable populations from the fore mentioned countries. Ensuring the ethical conduct of North-South collaborations in research is a process fraught with difficulties. The background conditions under which such collaborations take place include extreme differentials in available income and power, as well as a past history of colonialism, while differences in culture can add a new layer of complications. In this context, up-to-date case studies of unethical conduct are essential for research ethics training.


Author : Martín M. Kowalewski
Paul A. Garber
Publisher : Springer
Release : 2014-12-04
Page : 440
Category : Science
ISBN 13 : 1493919601
Description :


Howler monkeys (genus Alouatta) comprise twelve species of leaf-eating New World monkeys that range from southern Mexico through northern Argentina. This genus is the most widespread of any New World primate taxa, and can be found to inhabit a range of forest types from undisturbed rainforest to severely anthropogenically impacted forest fragments. Although there have been many studies on individual species of howler monkeys, this book is the first comprehensive volume to place information on howler behavior and biology within a theoretical framework of ecological and social adaptability. This is the second of two volumes devoted to the genus Alouatta. This volume: · Examines behavioral and physiological mechanisms that enable howler monkeys to exploit highly disturbed and fragmented habitats · Presents models of howler monkey diet, social organization, and mating systems that can also inform researchers studying Old World colobines, apes, and other tropical mammals These goals are achieved in a collection of chapters written by a distinguished group of scientists on the feeding ecology, behavior, mating strategies, and management and conservation of howlers. This book also contains chapters on the howler microbiome, the concept of behavioral variability, sexual selection, and the role of primates in forest regeneration.


Author : Philip Hershkovitz
Publisher : University of Chicago Press
Release : 1977-12-01
Page : 1132
Category : Nature
ISBN 13 : 9780226327884
Description :


In this long-awaited work, Philip Hershkovitz provides the most thorough and comprehensive treatise ever published on New World monkeys. The volume gives a detailed account of the origin, evolution, dispersal, and behavior of platyrrhines and a systematic arrangement of all known forms, living and extinct. During an eleven-year period, Hershkovitz examined more than 3,100 museum-preserved specimens and relevant primate fossils and observed hundreds of animals in captivity and thousands in the wild state. He presents his results in an elegant and encyclopedic text, lavishly illustrated with 520 figures and 7 color plates. Hershkovitz opens the study with a brief history and a definition, characterization, and comparison of primates as a taxonomic unit. Basing his work on nearly all known genera of living primates, the author deals with New World monkeys from comparative anatomical and evolutionary points of view. He examines display characters, pelage, the evolution of color patterns, primate locomotion, cranial and dental morphology, and the central nervous system. The final and most extensive part of the volume is devoted to the taxonomy and biology of the family Callitrichidae, comprising marmosets and tamarins, and the family Callimiconidae, represented by the callimico alone. Hershkovitz concludes with an exhaustive bibliography of more than 2,500 published works and a gazetteer of essential geographic data.


Author : National Research Council
Commission on Life Sciences
Publisher : National Academies Press
Release : 1998-11-03
Page : 184
Category : Science
ISBN 13 : 0309176506
Description :


A 1985 amendment to the Animal Welfare Act requires those who keep nonhuman primates to develop and follow appropriate plans for promoting the animals' psychological well-being. The amendment, however, provides few specifics. The Psychological Well-Being of Nonhuman Primates recommends practical approaches to meeting those requirements. It focuses on what is known about the psychological needs of primates and makes suggestions for assessing and promoting their well-being. This volume examines the elements of an effective care program--social companionship, opportunities for species-typical activity, housing and sanitation, and daily care routines--and provides a helpful checklist for designing a plan for promoting psychological well-being. The book provides a wealth of specific and useful information about the psychological attributes and needs of the most widely used and exhibited nonhuman primates. Readable and well-organized, it will be welcomed by animal care and use committees, facilities administrators, enforcement inspectors, animal advocates, researchers, veterinarians, and caretakers.


Author :
Publisher :
Release : 1986
Page : 441
Category : Animal experimentation
ISBN 13 :
Description :