The Organic Chemistry Of Isotopic Labelling Download Ebook PDF Epub Online

Author : James R. Hanson
Publisher : Royal Society of Chemistry
Release : 2011-01
Page : 184
Category : Science
ISBN 13 : 1849731888
Description :


The chemical synthesis of isotopically labelled compounds is a pre-requisite for many chemical, biochemical and medicinal investigations. The constraints imposed by the requirements for regiospecific labelling and, in some instances, the time-scale of the synthesis often lead to quite different synthetic strategies to those that are used for the unlabelled material. Whilst there are many specialist papers, reviews and long books devoted to particular isotopes, there is no currently available short introductory book devoted to the organic chemistry of isotopic labelling. The aim of this book is to introduce research workers to a variety of methods that have been used to achieve these synthetic labelling objectives before exploring a particular method in detail. It covers a number of different isotopes and the methods that have been used to introduce them into organic compounds. Labelling methods also provide useful undergraduate teaching examples of modern synthetic reactions and their stereochemical consequences using relatively simple substrates. The book will therefore have a wider appeal than just those involved in using isotopes in research such as environmental and pharmaceutical chemists as well as organic chemists.


Author : James R Hanson
Publisher : Royal Society of Chemistry
Release : 2019-04-05
Page : 200
Category : Science
ISBN 13 : 1788018184
Description :


The chemical synthesis of isotopically labelled compounds is a pre-requisite for many chemical, biochemical and medicinal investigations. The constraints imposed by the requirements for regiospecific labelling and, in some instances, the time-scale of the synthesis often lead to quite different synthetic strategies to those that are used for the unlabelled material. Whilst there are many specialist papers, reviews and long books devoted to particular isotopes, there is no currently available short introductory book devoted to the organic chemistry of isotopic labelling. The aim of this book is to introduce research workers to a variety of methods that have been used to achieve these synthetic labelling objectives before exploring a particular method in detail. It covers a number of different isotopes and the methods that have been used to introduce them into organic compounds. Labelling methods also provide useful undergraduate teaching examples of modern synthetic reactions and their stereochemical consequences using relatively simple substrates. The book will therefore have a wider appeal than just those involved in using isotopes in research such as environmental and pharmaceutical chemists as well as organic chemists.


Author : Søren Christian Schou
Københavns Universitet. Farmaceutiske Fakultet
Publisher :
Release : 2010
Page : 145
Category :
ISBN 13 : 9788792199898
Description :



Author :
Publisher : Academic Press
Release : 2015-11-26
Page : 634
Category : Medical
ISBN 13 : 0128030801
Description :


Isotope Labeling of Biomolecules – Labeling Methods, the latest volume of the Methods in Enzymology series contains comprehensive information on stable isotope labeling methods and applications for biomolecules. Contains contributions from leading authorities in the field of isotope labeling of biomolecules Informs and updates on the latest developments in the field Provides comprehensive information on stable isotope labeling methods and applications for biomolecules


Author : Thomas A. Baillie
John R. Jones
Publisher :
Release : 1988
Page : 861
Category :
ISBN 13 :
Description :


Stable isotopes (2H, 13C) are useful for studies on the metabolism of endogenous or exogenous compounds. GC/MS makes it possible to measure partial loss of 2H by exchange from polydeute-rated molecules and to detect compartmentation of precursors. Oxidoreduction can be studied by measurements of the loss of isotope from the carbon carrying the hydroxyl group. Label in the coenzyme can be corrected for by the use of mixtures of differently labelled compounds. Isotope effects can be used to study mechanisms in vitro and pathways in vivo. Labelling in vivo with 2H-substrates makes it possible to distinguish coenzyme pools. Topics discussed in this symposia include: Synthesis and Applications of Organic Compounds Labelled With Isotopic Hydrogen; Applications of Stable Isotopes and NMR Spectroscopy for In Vivo Studies; Radiation-Induced Reactions; Applications of Isotopically-Labelled Compounds in Clinical Research; Isotopes in Organic and Bio-Organic Reaction Mechanisms; New Techniques in Isotopic Analysis; Synthesis and Application of Organic Compounds Labelled With Iodine Isotopes; Synthesis of Isotopically-Labelled Compounds Via Organometallic Chemistry; Synthesis and Applications of Organic Compounds Labelled With Isotopic Carbon, Sulphur and Other Isotopes; The Use of Isotopically Labelled Compounds in Studies of Drug Metabolism, Disposition and Toxicity; Synthesis and Applications of Labelled Compounds in Positron Emission Trans-Axial Tomography; Applications of Radioactively-Labelled Compounds to In Vitro and In Vivo Research.(AW).


Author : Mar Gómez Gallego
Miguel A. Sierra
Publisher : Springer Science & Business Media
Release : 2012-12-06
Page : 290
Category : Science
ISBN 13 : 3642187889
Description :


Organic Reaction Mechanisms shows readers how to interpret the experimental data obtained from an organic reaction, and specifically how an organic reaction mechanism can be considered or rejected based on the analysis of the experimental evidence. Whilst examining a series of selected examples of mechanisms, the text focuses on real cases and discusses them in detail. The examples are arranged to elucidate key aspects of organic reaction mechanisms. The authors employ all the types of information that the authors of the original work considered useful and necessary, including spectroscopic data, kinetic and thermodynamic data, isotopic labelling and organic reactivity. The book makes an excellent primer for advanced undergraduates in chemistry who are preparing for exams and is also useful for graduate students and instructors.


Author : Rolf Voges
J. Richard Heys
Publisher : John Wiley & Sons
Release : 2009-03-12
Page : 682
Category : Science
ISBN 13 : 9780470743430
Description :


Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.


Author : Enrico Marcantoni
Gabriele Renzi
Publisher :
Release : 2009
Page : 400
Category : Science
ISBN 13 : 9788886208581
Description :


Discusses some of the major developments that have taken place in the field of organic synthesis. This volume serves as a useful reference source for students and researchers in both academia and industry.


Author : Howard Maskill
Publisher : John Wiley & Sons
Release : 2008-04-15
Page : 392
Category : Science
ISBN 13 : 0470994169
Description :


A range of alternative mechanisms can usually be postulated for most organic chemical reactions, and identification of the most likely requires detailed investigation. Investigation of Organic Reactions and their Mechanisms will serve as a guide for the trained chemist who needs to characterise an organic chemical reaction and investigate its mechanism, but who is not an expert in physical organic chemistry. Such an investigation will lead to an understanding of which bonds are broken, which are made, and the order in which these processes happen. This information and knowledge of the associated kinetic and thermodynamic parameters are central to the development of safe, efficient, and profitable industrial chemical processes, and to extending the synthetic utility of new chemical reactions in chemical and pharmaceutical manufacturing, and academic environments. Written as a coherent account of the principal methods currently used in mechanistic investigations, at a level accessible to academic researchers and graduate chemists in industry, the book is highly practical in approach. The contributing authors, an international group of expert practitioners of the techniques covered, illustrate their contributions by examples from their own research and from the relevant wider chemical literature. The book covers basic aspects such as product analysis, kinetics, catalysis, and investigation of reactive intermediates. It also includes material on significant recent developments, e.g. computational chemistry, calorimetry, and electrochemistry, in addition to topics of high current industrial relevance, e.g. reactions in multiphase systems, and synthetically useful reactions involving free radicals and catalysis by organometallic compounds.


Author : Xianlin Han
Publisher : John Wiley & Sons
Release : 2016-05-02
Page : 496
Category : Science
ISBN 13 : 1118893123
Description :


Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes


Author : B. J. Wakefield
Publisher : Elsevier
Release : 2013-10-22
Page : 348
Category : Science
ISBN 13 : 1483278700
Description :


The Chemistry of Organolithium Compounds is a comprehensive review of the status of organolithium compound chemistry. This book is composed of four parts and nineteen chapters that particularly describe the reactions involving these compounds The first part highlights the constitution of organolithium compounds, specifically in the absence and presence of electron donors, as well as the configurational stability of these compounds. The second part deals with their preparation from organic halides and lithium metal involving metallation and metal-halogen exchange, while the third part focuses on their organic synthesis. The fourth part considers the synthesis of organometallic compound derivatives from main group and transition metals. This book will prove useful to organic chemists and organic chemistry researchers.


Author : Jeevan Prasain
Publisher : BoD – Books on Demand
Release : 2016-12-28
Page : 216
Category : Science
ISBN 13 : 9535128531
Description :


Metabolomics: Fundamentals and Applications authoritatively presents the basic principles and applications of metabolomics. Topics covered in this book range from the analysis of metabolites from different biological sources and their data processing and statistical analysis. This book serves as a basic guide for a wide range of audiences from less familiar with metabolomics techniques to more experienced researchers seeking to understand complex biological systems from the systems biology approach.


Author : James R. Hanson
Publisher : Royal Society of Chemistry
Release : 2008-08-14
Page : 221
Category : Science
ISBN 13 : 0854041362
Description :


Fungi occupy an important place in the natural world, as non-photosynthetic organisms, they obtain their nutrients from the degradation of organic material. They use many of their secondary metabolites to secure a place in a competitive natural environment and to protect themselves from predation. The diverse structures, biosyntheses and biological activities of fungal metabolites have attracted chemists for many years. Fungi are ubiquitous and their activities affect many aspects of our daily lives whether it be as sources of pharmaceuticals and food or as spoilage organisms and the causes of diseases in plants and man. The chemistry of the fungi involved in these activities has been the subject of considerable study particularly over the last fifty years. Although their ramifications can be large as in the spread of plant diseases, the quantities of the metabolites which could be isolated precluded much chemical work until the advent of spectroscopic methods. Whereas many natural products derived from plants were isolated prior to the 1960s on a scale which permitted extensive chemical degradation, this was rarely the case for fungal metabolites. This book is an introduction to the chemistry of fungal metabolites. The aim is to illustrate within the context of fungal metabolites, the historical progression from chemical to spectroscopic methods of structure elucidation, the development in biosynthetic studies from establishing sequences and mechanisms to chemical enzymology and genetics and the increasing understanding of the biological roles of natural products. The book begins with a historical introduction followed by a description of the general chemical features which contribute to the growth of fungi. There are many thousands of fungal metabolites whose structures are known and the book does not aim to list them all as there are databases to fulfill this role. The book's aim is to describe some of the more important metabolites classified according to their biosynthetic origin. Biosynthesis provides a unifying feature underlying the diverse structures of fungal metabolites and the chapters covering this area begin with a general outline of the relevant biosynthetic pathway before presenting a detailed description of particular metabolites. Investigations into these biosyntheses have utilized many subtle isotopic labelling experiments and compounds that are fungal pigments and those which are distinctive metabolites of the more conspicuous Basidiomycetes are treated separately. Many fungal metabolites are involved in the interactions of fungi with plants and others are toxic to man and some of these are described in further chapters. Fungi have the ability to transform chemicals in ways which can complement conventional reactions and the use of fungi as reagents forms the subject of the final chapter. This book will be particularly useful to anybody about to embark on a career in chemical microbiology by providing an overall perspective of fungal metabolites as well as an essential reference tool for more general chemists.


Author : Pierre Vogel
Kendall N. Houk
Publisher : John Wiley & Sons
Release : 2019-08-08
Page : 1382
Category : Science
ISBN 13 : 3527819274
Description :


Provides the background, tools, and models required to understand organic synthesis and plan chemical reactions more efficiently Knowledge of physical chemistry is essential for achieving successful chemical reactions in organic chemistry. Chemists must be competent in a range of areas to understand organic synthesis. Organic Chemistry provides the methods, models, and tools necessary to fully comprehend organic reactions. Written by two internationally recognized experts in the field, this much-needed textbook fills a gap in current literature on physical organic chemistry. Rigorous yet straightforward chapters first examine chemical equilibria, thermodynamics, reaction rates and mechanisms, and molecular orbital theory, providing readers with a strong foundation in physical organic chemistry. Subsequent chapters demonstrate various reactions involving organic, organometallic, and biochemical reactants and catalysts. Throughout the text, numerous questions and exercises, over 800 in total, help readers strengthen their comprehension of the subject and highlight key points of learning. The companion Organic Chemistry Workbook contains complete references and answers to every question in this text. A much-needed resource for students and working chemists alike, this text: -Presents models that establish if a reaction is possible, estimate how long it will take, and determine its properties -Describes reactions with broad practical value in synthesis and biology, such as C-C-coupling reactions, pericyclic reactions, and catalytic reactions -Enables readers to plan chemical reactions more efficiently -Features clear illustrations, figures, and tables -With a Foreword by Nobel Prize Laureate Robert H. Grubbs Organic Chemistry: Theory, Reactivity, and Mechanisms in Modern Synthesis is an ideal textbook for students and instructors of chemistry, and a valuable work of reference for organic chemists, physical chemists, and chemical engineers.


Author : David C. Coleman
D. A. Crossley, Jr.
Publisher : Elsevier
Release : 2004-08-11
Page : 408
Category : Science
ISBN 13 : 0080472818
Description :


This fully revised and expanded edition of Fundamentals of Soil Ecology continues its holistic approach to soil biology and ecosystem function. Students and ecosystem researchers will gain a greater understanding of the central roles that soils play in ecosystem development and function. The authors emphasize the increasing importance of soils as the organizing center for all terrestrial ecosystems and provide an overview of theory and practice of soil ecology, both from an ecosystem and evolutionary biology point of view. This volume contains updated and greatly expanded coverage of all belowground biota (roots, microbes and fauna) and methods to identify and determine its distribution and abundance. New chapters are provided on soil biodiversity and its relationship to ecosystem processes, suggested laboratory and field methods to measure biota and their activities in ecosystems.. Contains over 60% new material and 150 more pages Includes new chapters on soil biodiversity and its relationship to ecosystem function Outlines suggested laboratory and field methods Incorporates new pedagogical features Combines theoretical and practical approaches


Author : Jaemoon Yang
Publisher : Elsevier
Release : 2016-05-15
Page : 130
Category : Science
ISBN 13 : 0128110414
Description :


Deuterium: Discovery and Applications in Organic Chemistry provides a well-illustrated overview of the discovery of 2H or heavy hydrogen, the stable hydrogen isotope with both a proton and a neutron in its nucleus. The work introduces the isotope, its discovery, physical properties, nomenclature, and common compounds, also exploring its application in organic chemistry through classic and recent examples from literature. Finally, the book devotes one chapter to Deuterium in medicinal chemistry and the biological effects of Deuterium Oxide, better known as D2O. Provides unique coverage not found elsewhere that is presented in an accessible, dedicated short work Contains practical information and examples on the use of Deuterium (D or 2H, Heavy Hydrogen) in organic synthesis Presents a detailed description of Deuterium’s discovery and applications in the pharmaceutical industry


Author : Enrico Marcantoni
Gabriele Renzi
Publisher :
Release : 2006-06-30
Page : 354
Category : Science
ISBN 13 : 9788886208321
Description :


Discusses some of the major developments that have taken place in the field of organic synthesis. This volume serves as a useful reference source for students and researchers in both academia and industry.


Author : Jordi Llop
Vanessa Gomez-Vallejo
Publisher : CRC Press
Release : 2016-03-30
Page : 544
Category : Medical
ISBN 13 : 9814669091
Description :


Nanoparticles may be used in industrial processes, incorporated into consumer products, or applied as biomedical agents. Isotopic (radio)labeling is one of the most powerful methods for nanoparticle tracing in experimental studies. This book presents an introduction to some commonly used nanomaterials, describes various methods with which they may be radiolabeled, and provides illustrative examples of applications of the labeled particles. Finally, it discusses the use of nanomaterials in radiotherapy, the stable isotope labeling technique, and operational health and safety aspects related to the manipulation of nanoparticles in controlled areas. The book will appeal to anyone involved in nanotechnology, molecular imaging, radiochemistry, and nanomedicine.


Author : Societa Chimica Italiana
Publisher :
Release : 2012-09-30
Page : 350
Category : Science
ISBN 13 : 9788886208710
Description :


Discusses some of the major developments that have taken place in the field of organic synthesis, analytical methods and synthetic applications in (bio)material sciences. This volume serves as a useful reference source for students and researchers in both academia and industry.


Author : Norman Kharasch
Walter Wolf
Publisher : Elsevier
Release : 2013-10-22
Page : 356
Category : Reference
ISBN 13 : 1483149374
Description :


Index to Reviews, Symposia Volumes and Monographs in Organic Chemistry for the Period 1940-1960 presents a resume of published monographs, reviews, and symposia lectures in organic chemistry. The editors adopted the plan of listings by symposia volume or journal, backed up by the total subject and author indexes. In this way the user can readily locate a particular article through the author index or the subject index; or should he recall that an article appeared in a particular source, the chronological listing in that source can be scanned quickly. The Index gives a convenient overview of the accomplishments of organic chemists during this very prolific period of the growth of the field. Frequently, several articles on the same or similar subject appear, hence the historical perspective can be sensed by rapid evaluation of the reviews selected. This Index will be useful to research workers, teachers and students. It will also assist editors and authors to select specific areas which require critical review.